Negative regulation of cardiac muscle adaptation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, TPM2, and FOXO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle adaptation activity versus IGFBP7 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IGFBP7 →	+1.018	+0.223	<.001	<.001	3	7
BRCA	TPM2 →	+1.297	+0.331	<.001	<.001	3	7
GBM	FOXO1 →	+0.351	+0.108	.007	.009	3	7
BRCA	MYL9 →	+1.403	+0.331	<.001	<.001	3	6
LUAD	PDLIM2 →	+0.482	+0.242	<.001	<.001	3	6
BRCA	TAGLN →	+1.388	+0.278	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010616 vs IGFBP7 — GBM

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