Negative regulation of cardiac muscle adaptation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRH, RTL8C, and GPCPD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRH grouped by Negative regulation of cardiac muscle adaptation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CRH →	+0.161	+0.905	.003	.005	3	5
LUNG_SCLC	RTL8C →	+1.581	+1.899	<.001	<.001	3	5
BONE	GPCPD1 →	+1.109	+1.087	.001	.008	3	4
CNS	TBL3 →	-0.397	-0.891	.001	<.001	3	4
PANCREAS	MAL2 →	-4.203	-1.340	.004	.001	3	4
BLOOD_Leukemia	SFXN2 →	-0.959	-0.850	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRH by Negative regulation of cardiac muscle adaptation activity — CNS

Explore this box plot interactively →