Negative regulation of cardiac muscle adaptation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD3, ABLIM3, and ERRFI1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle adaptation activity versus SMAD3 in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMAD3 →	+1.774	+0.140	<.001	<.001	3	15
LUNG_NSCLC_LUSC	ABLIM3 →	+2.926	+0.293	<.001	<.001	3	14
LUNG_NSCLC_LUSC	ERRFI1 →	+2.429	+0.264	<.001	<.001	3	14
BONE	MYOF →	+3.913	+0.227	<.001	<.001	3	14
LIVER	RRAS →	+2.493	+0.309	.001	.001	3	14
BONE	CD59 →	+2.029	+0.260	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010616 vs SMAD3 — BLOOD_Leukemia

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