Negative regulation of cardiac muscle adaptation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC21, CCDC136, and MAST1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle adaptation activity versus H2BC21 in LARGE_INTESTINE (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H2BC21 →	+2.407	+0.159	<.001	.001	3	4
SOFT_TISSUE	CCDC136 →	-2.117	-0.240	.002	.007	2	5
LUNG_NSCLC_LUAD	MAST1 →	-0.753	-0.173	.004	.002	3	3
LUNG_NSCLC_LUAD	ZFP69B →	-0.921	-0.139	<.001	<.001	3	3
LUNG_NSCLC_LUAD	PDXP →	-0.597	-0.124	.004	.001	3	3
LARGE_INTESTINE	TFIP11 →	-0.985	-0.191	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010616 vs H2BC21 — LARGE_INTESTINE

Explore this scatter interactively →