Negative regulation of cardiac muscle adaptation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP2B4, SMAD3, and CARS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle adaptation activity versus ATP2B4 in LARGE_INTESTINE (Pearson r = -0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP2B4 →	-1.629	-0.158	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	SMAD3 →	-1.274	-0.141	<.001	.002	3	8
LARGE_INTESTINE	CARS1 →	-1.732	-0.221	<.001	.002	3	4
BLOOD_Leukemia	LMNA →	+4.939	+1.972	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ERRFI1 →	-2.645	-0.291	.001	.003	3	3
SOFT_TISSUE	PDHX →	+0.701	+0.168	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010616 vs ATP2B4 — LARGE_INTESTINE

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