Regulation of cardiac muscle adaptation

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle adaptation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMNB2, LTBP4, and UBE2O_S896, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle adaptation activity versus LMNB2 in LUAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LMNB2 →	+0.232	+0.069	.001	<.001	3	7
UCEC	LTBP4 →	+0.545	+0.084	.002	.003	3	6
LSCC	UBE2O_S896 →	-0.431	-0.073	.004	.001	3	6
LSCC	PHF2_S655 →	+0.570	+0.068	.001	.005	3	6
GBM	RFXANK →	+0.270	+0.098	<.001	<.001	3	5
GBM	USP10_S547 →	-0.462	-0.084	.005	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010612 vs LMNB2 — LUAD

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