Regulation of cardiac muscle adaptation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle adaptation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFA, ATXN10, and CRYBG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle adaptation activity versus TGFA in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TGFA →	+1.640	+0.155	.003	.009	3	5
BLOOD_Lymphoma	ATXN10 →	-1.598	-1.104	.007	.008	3	5
UPPER_AERODIGESTIVE_TRACT	CRYBG2 →	+1.750	+0.180	<.001	<.001	3	5
LARGE_INTESTINE	SNU13 →	-0.888	-0.240	<.001	<.001	3	5
BLOOD_Lymphoma	TVP23C →	+2.261	+1.388	<.001	.007	3	5
SOFT_TISSUE	THSD4 →	+3.880	+0.236	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010612 vs TGFA — BONE

Explore this scatter interactively →