Positive regulation of cytoplasmic mRNA processing body assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytoplasmic mRNA processing body assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCC2, RPS8, and SPAG9_S332, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic mRNA processing body assembly activity versus SMARCC2 in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMARCC2 →	+0.269	+0.096	<.001	<.001	3	7
BRCA	RPS8 →	-0.329	-0.087	<.001	<.001	3	6
COAD	SPAG9_S332 →	-0.605	-0.057	<.001	<.001	3	6
HNSC	PGAM1_S31 →	-0.883	-0.127	<.001	<.001	3	6
HNSC	RPS2 →	-0.197	-0.075	<.001	.002	3	5
BRCA	RPS3A →	-0.207	-0.065	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010606 vs SMARCC2 — HNSC

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