Positive regulation of cytoplasmic mRNA processing body assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytoplasmic mRNA processing body assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL4A2-AS2, ZFP82, and PPIC-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic mRNA processing body assembly activity versus COL4A2-AS2 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL4A2-AS2 →	+0.477	+0.582	.007	.005	3	3
HNSC	ZFP82 →	+0.459	+0.644	.009	.004	3	3
LUAD	PPIC-AS1 →	+0.357	+0.516	<.001	.002	3	3
COAD	CACNA1C-AS3 →	+0.050	+0.978	.008	<.001	3	3
CCRCC	RPL7P21 →	-0.317	-0.469	.008	.001	3	3
CCRCC	GOLGA2P5 →	-0.520	-0.444	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010606 vs COL4A2-AS2 — GBM

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