Positive regulation of cytoplasmic mRNA processing body assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoplasmic mRNA processing body assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1BP1, COPRS, and CASZ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic mRNA processing body assembly activity versus ITGB1BP1 in LARGE_INTESTINE (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGB1BP1 →	+0.947	+1.019	.002	.007	3	4
LARGE_INTESTINE	COPRS →	+0.615	+0.987	.003	.001	3	4
LARGE_INTESTINE	CASZ1 →	-1.809	-1.033	<.001	.009	3	3
LARGE_INTESTINE	IRF2BP2 →	-1.171	-1.071	.002	.004	3	3
CNS	TTC31 →	+0.579	+0.925	.006	.003	3	3
CNS	ALDH6A1 →	+0.629	+0.980	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010606 vs ITGB1BP1 — LARGE_INTESTINE

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