Regulation of cytoplasmic mRNA processing body assembly

Across TCGA cell cohorts, RNA activity of the Regulation of cytoplasmic mRNA processing body assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAN3, CNOT1, and TNIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAN3 grouped by Regulation of cytoplasmic mRNA processing body assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PAN3 →	-0.223	-1.705	<.001	<.001	3	6
BREAST	CNOT1 →	-0.352	-0.266	<.001	<.001	3	5
BLOOD_Myeloma	TNIP1 →	-0.194	-1.733	.006	<.001	3	4
BLOOD_Myeloma	OFD1 →	+0.322	+2.162	.004	<.001	3	4
URINARY_TRACT	CORO1B →	-0.336	-2.096	.006	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CCDC69 →	+0.236	+0.270	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAN3 by Regulation of cytoplasmic mRNA processing body assembly activity — PANCREAS

Explore this box plot interactively →