Regulation of cytoplasmic mRNA processing body assembly

Across TCGA cell cohorts, RNA activity of the Regulation of cytoplasmic mRNA processing body assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC159, ZNF316, and RAB11B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC159 grouped by Regulation of cytoplasmic mRNA processing body assembly-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCDC159 →	-1.111	-1.260	.001	.004	3	5
BLOOD_Lymphoma	ZNF316 →	+0.854	+1.772	.007	.007	3	4
LARGE_INTESTINE	RAB11B →	-0.712	-1.103	.003	.005	3	4
BLOOD_Leukemia	DAP →	-0.581	-1.032	.006	.004	3	4
OVARY	APTX →	+0.595	+1.065	<.001	.001	3	4
LARGE_INTESTINE	HFE →	-1.225	-1.223	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC159 by Regulation of cytoplasmic mRNA processing body assembly activity — OVARY

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