Regulation of endothelial cell migration

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R7, SPRYD7, and CCDC77, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial cell migration activity versus PPP1R7 in OESOPHAGUS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PPP1R7 →	+0.767	+0.145	.001	.005	2	6
STOMACH	SPRYD7 →	+1.105	+0.305	.002	.001	3	5
SOFT_TISSUE	CCDC77 →	-1.119	-0.249	.001	.002	3	4
OESOPHAGUS	TPK1 →	+0.879	+0.166	.006	.005	3	4
OESOPHAGUS	CCSER2 →	+0.993	+0.170	.002	.001	3	4
BLOOD_Leukemia	SKAP2 →	+2.675	+0.151	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010594 vs PPP1R7 — OESOPHAGUS

Explore this scatter interactively →