Negative regulation of lamellipodium assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RMI1, ABI3, and LY86, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lamellipodium assembly activity versus RMI1 in LSCC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RMI1 →	-0.642	-0.253	.003	.006	3	4
LSCC	ABI3 →	+0.712	+0.298	<.001	.002	3	4
LSCC	LY86 →	+0.605	+0.217	.001	<.001	3	4
LSCC	SGO2 →	-0.574	-0.226	<.001	.003	3	4
CCRCC	RNASEK →	+0.306	+0.793	<.001	<.001	3	3
CCRCC	HMGA1P4 →	+0.459	+0.654	.003	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010593 vs RMI1 — LSCC

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