Negative regulation of lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAB21L3, NCAPG2, and NELFB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAB21L3 grouped by Negative regulation of lamellipodium assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MAB21L3 →	+0.297	+0.527	.006	.004	3	4
URINARY_TRACT	NCAPG2 →	-0.957	-1.890	.002	<.001	3	3
SOFT_TISSUE	NELFB →	-0.681	-0.329	<.001	<.001	3	3
SOFT_TISSUE	SUOX →	+1.056	+0.296	.004	.001	3	3
BLOOD_Leukemia	EI24 →	+0.788	+0.297	.001	<.001	3	3
SOFT_TISSUE	GCNT1 →	-1.882	-0.219	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAB21L3 by Negative regulation of lamellipodium assembly activity — KIDNEY

Explore this box plot interactively →