Regulation of lamellipodium assembly

Across TCGA patient cohorts, RNA activity of the Regulation of lamellipodium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERBP1, RSU1, and MRPL10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lamellipodium assembly activity versus SERBP1 in HNSC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SERBP1 →	-0.258	-0.054	<.001	<.001	3	9
BRCA	RSU1 →	+0.308	+0.032	<.001	<.001	3	7
OV	MRPL10 →	-0.385	-0.033	.001	<.001	3	7
BRCA	SYNPO →	+0.347	+0.031	<.001	<.001	3	7
GBM	GEM_S23 →	+0.755	+0.057	<.001	<.001	3	7
HNSC	SEPTIN4 →	+0.278	+0.039	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010591 vs SERBP1 — HNSC

Explore this scatter interactively →