Regulation of lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, CTSZ, and TRIM27, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THBS1 grouped by Regulation of lamellipodium assembly-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	THBS1 →	+3.938	+0.439	<.001	<.001	3	7
OVARY	CTSZ →	+1.772	+0.386	.009	.001	2	6
STOMACH	TRIM27 →	-0.684	-1.071	.006	.005	3	5
OVARY	TNFAIP1 →	+1.072	+0.466	.002	.006	3	5
LARGE_INTESTINE	KRI1 →	-0.726	-0.975	<.001	<.001	3	5
LARGE_INTESTINE	RPRD1A →	-0.842	-0.867	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THBS1 by Regulation of lamellipodium assembly activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →