Regulation of lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Regulation of lamellipodium assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX19, PI4KA, and PLP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBX19 grouped by Regulation of lamellipodium assembly-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TBX19 →	+0.152	+0.112	.001	<.001	3	6
STOMACH	PI4KA →	+0.286	+0.084	.004	.001	3	5
PANCREAS	PLP2 →	-0.203	-0.216	<.001	<.001	3	5
LUNG_NSCLC_LUAD	FAF1 →	-0.122	-0.111	.002	<.001	3	5
URINARY_TRACT	DUSP29 →	-0.260	-0.100	.006	<.001	3	4
URINARY_TRACT	PRKCZ →	-0.250	-0.088	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBX19 by Regulation of lamellipodium assembly activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →