Regulation of lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAP1, FSCN1, and WASF2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lamellipodium assembly activity versus CAP1 in PANCREAS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAP1 →	+0.956	+0.095	.001	.001	3	13
BREAST	FSCN1 →	+2.693	+0.128	<.001	<.001	3	13
BLOOD_Lymphoma	WASF2 →	+1.001	+0.099	<.001	<.001	3	13
LARGE_INTESTINE	GNAI2 →	+1.134	+0.101	<.001	<.001	3	12
BLOOD_Leukemia	ELK3 →	+1.343	+0.070	<.001	<.001	3	12
BREAST	LUZP1 →	+1.503	+0.129	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010591 vs CAP1 — PANCREAS

Explore this scatter interactively →