Regulation of lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Regulation of lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBIP, CFL1, and TWF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lamellipodium assembly activity versus IKBIP in URINARY_TRACT (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IKBIP →	+1.708	+0.377	.002	.005	3	7
PANCREAS	CFL1 →	+0.785	+0.355	.001	<.001	3	6
PANCREAS	TWF2 →	+0.734	+0.278	<.001	.005	2	7
SOFT_TISSUE	HERC4 →	+1.228	+0.291	.004	<.001	3	6
BLOOD_Leukemia	ELK3 →	+1.487	+0.212	<.001	<.001	3	6
LUNG_NSCLC_LUSC	TMEM9B →	+0.793	+0.300	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010591 vs IKBIP — URINARY_TRACT

Explore this scatter interactively →