miRNA catabolic process

Across TCGA patient cohorts, RNA activity of the miRNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, FERMT2, and OLFML3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA catabolic process activity versus TLN1 in LSCC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TLN1 →	+0.173	+0.030	.002	.002	3	9
LSCC	FERMT2 →	+0.400	+0.041	<.001	<.001	3	8
CCRCC	OLFML3 →	+0.749	+0.053	<.001	<.001	3	8
BRCA	CNN3 →	+0.466	+0.043	<.001	<.001	3	8
PDAC	YME1L1 →	-0.412	-0.044	<.001	<.001	3	7
BRCA	CAVIN3 →	+0.496	+0.049	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010587 vs TLN1 — LSCC

Explore this scatter interactively →