miRNA catabolic process

Across TCGA cell cohorts, RNA activity of the miRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEPR, DHCR24, and ZNF518A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LEPR grouped by miRNA catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LEPR →	-0.698	-0.387	.001	.006	3	4
OESOPHAGUS	DHCR24 →	+1.868	+0.358	.006	<.001	3	3
BONE	ZNF518A →	+0.910	+0.422	.006	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PARP6 →	+1.319	+0.559	.003	<.001	3	3
BREAST	COL24A1 →	+0.254	+0.421	.009	.002	3	3
SKIN	PDIA3 →	+0.906	+0.418	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LEPR by miRNA catabolic process activity — BREAST

Explore this box plot interactively →