miRNA catabolic process

Across TCGA cell cohorts, RNA activity of the miRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIS3L2, RBP5, and RABL2A, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA catabolic process activity versus DIS3L2 in OVARY (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DIS3L2 →	+0.810	+0.109	.001	<.001	3	15
PANCREAS	RBP5 →	+0.698	+0.066	.002	.002	3	12
URINARY_TRACT	RABL2A →	+0.874	+0.107	.004	.008	2	12
URINARY_TRACT	MDM4 →	+1.323	+0.131	.001	<.001	3	11
LUNG_SCLC	PJVK →	+1.241	+0.114	.005	<.001	3	11
PANCREAS	PLA2G6 →	+1.143	+0.104	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010587 vs DIS3L2 — OVARY

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