miRNA catabolic process

Across TCGA cell cohorts, RNA activity of the miRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARF1, PLPP5, and RAET1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA catabolic process activity versus ARF1 in SKIN (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARF1 →	+0.835	+0.346	<.001	<.001	3	6
OVARY	PLPP5 →	+0.821	+0.147	<.001	.009	3	6
LARGE_INTESTINE	RAET1L →	-1.905	-0.227	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	SMAD1 →	+0.990	+0.330	.003	.004	3	5
BLOOD_Lymphoma	MICU3 →	+1.031	+0.114	<.001	.002	3	5
OVARY	PLPBP →	+0.679	+0.169	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010587 vs ARF1 — SKIN

Explore this scatter interactively →