miRNA metabolic process

Across TCGA patient cohorts, RNA activity of the miRNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSTL1, EZH2_T367, and ARHGEF17, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA metabolic process activity versus FSTL1 in BRCA (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FSTL1 →	+0.501	+0.025	<.001	.002	3	7
OV	EZH2_T367 →	-1.527	-0.065	<.001	<.001	3	7
HNSC	ARHGEF17 →	+0.168	+0.044	<.001	.004	3	7
BRCA	TIMP2 →	+0.602	+0.041	<.001	<.001	3	6
HNSC	FKBP7 →	+0.520	+0.065	<.001	.008	3	6
HNSC	RAI14 →	+0.307	+0.057	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010586 vs FSTL1 — BRCA

Explore this scatter interactively →