miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGUOK, SNRNP27, and BPNT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA metabolic process activity versus DGUOK in OESOPHAGUS (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DGUOK →	+0.628	+0.199	<.001	<.001	3	5
OESOPHAGUS	SNRNP27 →	+0.929	+0.204	<.001	<.001	3	5
OESOPHAGUS	BPNT1 →	+0.647	+0.187	.001	<.001	3	5
BLOOD_Myeloma	GLB1L2 →	+3.753	+0.238	<.001	<.001	3	4
BREAST	TMEM219 →	+0.920	+0.183	<.001	<.001	3	4
BREAST	NAXE →	+0.929	+0.202	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010586 vs DGUOK — OESOPHAGUS

Explore this scatter interactively →