Positive regulation of vascular endothelial growth factor production

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular endothelial growth factor production pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD4, BPHL, and C12orf76, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDCD4 grouped by Positive regulation of vascular endothelial growth factor production-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PDCD4 →	-2.463	-0.696	<.001	.001	3	4
LIVER	BPHL →	-0.758	-0.451	.002	<.001	3	4
BREAST	C12orf76 →	-0.873	-0.711	<.001	.005	3	4
LUNG_NSCLC_LUAD	ABTB1 →	-0.921	-0.526	.004	.007	3	4
LUNG_NSCLC_LUAD	STXBP1 →	-1.182	-0.694	.002	.003	3	4
BREAST	TMEM229B →	-1.736	-0.702	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDCD4 by Positive regulation of vascular endothelial growth factor production activity — BREAST

Explore this box plot interactively →