Positive regulation of vascular endothelial growth factor production

Across TCGA cell cohorts, RNA activity of the Positive regulation of vascular endothelial growth factor production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL32, CDC42SE1, and FAH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vascular endothelial growth factor production activity versus MRPL32 in SKIN (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MRPL32 →	-0.540	-0.222	.007	.001	3	4
SKIN	CDC42SE1 →	-0.697	-0.266	.007	.005	3	4
BONE	FAH →	+2.100	+0.357	<.001	<.001	3	4
BONE	NPW →	-4.625	-0.448	<.001	.004	3	4
BLOOD_Leukemia	PRAG1 →	-0.890	-0.211	.008	.005	3	4
BREAST	TVP23C →	+1.138	+0.250	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010575 vs MRPL32 — SKIN

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