Vascular endothelial growth factor production

Across TCGA patient cohorts, RNA activity of the Vascular endothelial growth factor production pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB2, GPR65, and LRRC25, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor production activity versus LILRB2 in LAML (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	LILRB2 →	+2.476	+0.068	<.001	<.001	3	31
LAML	GPR65 →	+1.152	+0.046	<.001	<.001	3	31
LAML	LRRC25 →	+2.162	+0.067	<.001	<.001	3	31
BLCA	SPI1 →	+1.637	+0.043	<.001	<.001	3	31
LAML	CD4 →	+1.582	+0.062	<.001	<.001	3	30
LAML	MS4A4A →	+2.109	+0.073	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010573 vs LILRB2 — LAML

Explore this scatter interactively →