Positive regulation of nuclear cell cycle DNA replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of nuclear cell cycle DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1B, NLRC4, and NONO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nuclear cell cycle DNA replication activity versus FCGR1B in GBM (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR1B →	-0.451	-0.418	<.001	.005	3	5
UCEC	NLRC4 →	-0.568	-0.422	<.001	.006	3	5
LSCC	NONO →	+0.475	+0.911	.001	.001	3	5
LSCC	LCP1 →	-0.580	-0.665	.006	.007	3	5
LSCC	AIF1 →	-0.458	-0.592	.005	.002	3	5
LSCC	SNHG20 →	+0.312	+0.615	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010571 vs FCGR1B — GBM

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