Positive regulation of nuclear cell cycle DNA replication

Across TCGA patient cohorts, RNA activity of the Positive regulation of nuclear cell cycle DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATRX_S1352, CSTF3, and ATRX_S1348, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nuclear cell cycle DNA replication activity versus ATRX_S1352 in OV (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ATRX_S1352 →	+2.101	+0.758	<.001	<.001	3	7
GBM	CSTF3 →	+0.281	+0.608	<.001	<.001	3	6
OV	ATRX_S1348 →	+1.021	+0.342	<.001	<.001	3	6
GBM	ATRX →	+0.547	+0.763	<.001	<.001	3	5
LUAD	SRRM1_S638 →	+0.420	+0.332	<.001	.002	3	5
LSCC	SRRM2_S1483 →	+0.645	+0.840	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010571 vs ATRX_S1352 — OV

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