Regulation of double-strand break repair via homologous recombination

Across TCGA patient cohorts, RNA activity of the Regulation of double-strand break repair via homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGO1, RFC5, and HELLS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair via homologous recombination activity versus SGO1 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SGO1 →	+0.670	+0.990	.002	.001	3	6
LSCC	RFC5 →	+0.757	+0.407	<.001	.005	3	5
GBM	HELLS →	+0.914	+0.678	.002	.009	2	6
LSCC	HROB →	+0.954	+0.363	<.001	.001	3	5
GBM	CDC25C →	+0.884	+0.720	.002	.004	3	5
GBM	PTH1R →	-0.666	-0.550	.008	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010569 vs SGO1 — HNSC

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