Regulation of double-strand break repair via homologous recombination

Across TCGA cell cohorts, RNA activity of the Regulation of double-strand break repair via homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF440, GALNT2, and FILIP1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF440 grouped by Regulation of double-strand break repair via homologous recombination-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF440 →	+1.125	+0.209	<.001	<.001	3	5
LUNG_NSCLC_LUSC	GALNT2 →	+1.106	+0.173	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	FILIP1L →	+2.446	+0.189	.006	.007	3	5
LIVER	PIGC →	+0.830	+0.157	.006	.007	3	4
PANCREAS	MTURN →	+1.283	+0.201	.001	<.001	3	4
SOFT_TISSUE	DVL1 →	+0.751	+0.136	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF440 by Regulation of double-strand break repair via homologous recombination activity — SOFT_TISSUE

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