Regulation of double-strand break repair via homologous recombination

Across TCGA cell cohorts, RNA activity of the Regulation of double-strand break repair via homologous recombination pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF775, CCL27, and MEX3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair via homologous recombination activity versus ZNF775 in STOMACH (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF775 →	+1.141	+0.174	.003	.005	3	6
BLOOD_Lymphoma	CCL27 →	-0.410	-0.200	.008	.001	2	6
STOMACH	MEX3A →	+3.108	+0.238	.001	.004	3	5
BREAST	ALMS1 →	+0.743	+0.126	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TMOD2 →	+0.671	+0.147	.003	.001	2	6
STOMACH	C1orf116 →	-2.505	-0.192	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010569 vs ZNF775 — STOMACH

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