Negative regulation of platelet activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of platelet activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGBL1, CRISPLD2, and F13A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of platelet activation activity versus ITGBL1 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGBL1 →	+1.175	+0.199	<.001	<.001	3	6
BRCA	CRISPLD2 →	+0.881	+0.135	.003	.003	2	6
BRCA	F13A1 →	+1.254	+0.188	<.001	<.001	3	5
BRCA	COL8A1 →	+1.323	+0.173	<.001	<.001	3	5
COAD	PDLIM3 →	+0.858	+0.259	.001	.008	3	5
BRCA	CALHM5 →	+0.504	+0.149	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010544 vs ITGBL1 — BRCA

Explore this scatter interactively →