Negative regulation of platelet activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of platelet activation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DZIP1L, NECAB3, and KIAA0895L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DZIP1L grouped by Negative regulation of platelet activation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DZIP1L →	-1.425	-1.496	.008	.001	3	4
BREAST	NECAB3 →	+0.830	+0.568	.001	.009	3	4
LARGE_INTESTINE	KIAA0895L →	+0.732	+0.814	.001	.003	3	4
LUNG_NSCLC_LUSC	PDCD2L →	+1.020	+1.154	<.001	.009	3	4
SKIN	C1orf56 →	-0.719	-0.978	.002	.008	3	3
BLOOD_Leukemia	PPP3CB →	+0.559	+1.126	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DZIP1L by Negative regulation of platelet activation activity — LIVER

Explore this box plot interactively →