Regulation of platelet activation

Across TCGA cell cohorts, RNA activity of the Regulation of platelet activation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPNE9, H1-10, and ROGDI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPNE9 grouped by Regulation of platelet activation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CPNE9 →	+0.110	+0.445	.001	.003	3	5
CNS	H1-10 →	+0.671	+0.712	.001	.006	3	3
CNS	ROGDI →	+0.786	+0.796	.003	.006	3	3
LARGE_INTESTINE	RAP1GDS1 →	-0.680	-0.766	<.001	.005	3	3
SOFT_TISSUE	EID3 →	-1.825	-1.069	.001	.006	3	3
BLOOD_Leukemia	MAPKAPK3 →	+1.224	+1.080	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPNE9 by Regulation of platelet activation activity — URINARY_TRACT

Explore this box plot interactively →