Regulation of platelet activation

Across TCGA cell cohorts, RNA activity of the Regulation of platelet activation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHKA, PRXL2B, and CITED4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of platelet activation activity versus CHKA in LARGE_INTESTINE (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHKA →	+0.973	+0.402	<.001	.004	3	5
STOMACH	PRXL2B →	-1.344	-0.317	.008	.002	3	5
STOMACH	CITED4 →	+1.431	+0.319	.004	<.001	3	5
KIDNEY	ID1 →	+1.973	+0.323	.007	.003	3	5
KIDNEY	TBX19 →	+0.808	+0.277	.007	.002	3	5
LUNG_NSCLC_LUSC	MACROD1 →	-1.614	-0.253	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010543 vs CHKA — LARGE_INTESTINE

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