Positive regulation of calcium ion transport into cytosol

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion transport into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LST1, DOK2, and ASPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transport into cytosol activity versus LST1 in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LST1 →	+0.612	+0.126	.002	.005	3	6
COAD	DOK2 →	+0.779	+0.169	<.001	.006	3	5
GBM	ASPA →	+0.890	+0.215	.002	<.001	3	5
GBM	STK35 →	-0.238	-0.125	.004	<.001	3	5
GBM	TAL1 →	+0.623	+0.128	.003	.008	3	5
GBM	LAIR1 →	+0.739	+0.132	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010524 vs LST1 — GBM

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