Positive regulation of calcium ion transport into cytosol

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion transport into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV1, ITGA3, and CAV2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transport into cytosol activity versus CAV1 in LUNG_NSCLC_LUSC (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CAV1 →	+6.251	+0.402	<.001	<.001	3	15
BONE	ITGA3 →	+3.728	+0.252	<.001	<.001	3	15
BREAST	CAV2 →	+4.212	+0.256	<.001	<.001	3	14
BONE	MYOF →	+4.623	+0.249	<.001	<.001	3	13
BONE	TNFRSF12A →	+3.812	+0.277	<.001	<.001	3	13
BLOOD_Leukemia	CAPN2 →	+1.878	+0.235	<.001	.007	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010524 vs CAV1 — LUNG_NSCLC_LUSC

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