Positive regulation of calcium ion transport into cytosol

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion transport into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC37A2, WNT5B, and ACADM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transport into cytosol activity versus SLC37A2 in PANCREAS (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC37A2 →	+3.961	+0.594	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	WNT5B →	+2.488	+0.329	<.001	<.001	3	5
PANCREAS	ACADM →	-1.187	-0.568	.004	<.001	3	5
BLOOD_Lymphoma	DUSP16 →	-2.195	-1.638	.007	.009	3	5
BONE	EMP1 →	+4.736	+0.465	.008	.004	3	5
OESOPHAGUS	C6orf120 →	-0.960	-0.377	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010524 vs SLC37A2 — PANCREAS

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