Regulation of calcium ion transport into cytosol

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion transport into cytosol pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF213, HIVEP3_S1964, and LGALS9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion transport into cytosol activity versus RNF213 in LSCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNF213 →	+0.346	+0.070	<.001	<.001	3	7
BRCA	HIVEP3_S1964 →	+0.750	+0.048	<.001	.003	3	7
GBM	LGALS9 →	+0.576	+0.079	<.001	<.001	3	7
GBM	CASP4 →	+0.621	+0.105	<.001	<.001	3	6
BRCA	HIVEP3_S948 →	+0.675	+0.065	.002	<.001	2	7
GBM	IFI35 →	+0.499	+0.110	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010522 vs RNF213 — LSCC

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