Regulation of calcium ion transport into cytosol

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion transport into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, SAA2, and USP6NL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion transport into cytosol activity versus MEFV in PDAC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MEFV →	+0.849	+0.155	<.001	<.001	3	5
GBM	SAA2 →	+1.626	+0.202	.001	.001	3	5
HNSC	USP6NL →	-0.391	-0.237	.004	.003	3	5
GBM	CLEC7A →	+1.328	+0.274	<.001	<.001	3	5
HNSC	BMP7 →	-1.194	-0.221	.001	.001	3	5
GBM	SLC15A3 →	+0.811	+0.221	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010522 vs MEFV — PDAC

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