Positive regulation of phospholipase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of phospholipase activity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBNA1BP2, MYCBP, and EXOSC5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EBNA1BP2 grouped by Positive regulation of phospholipase activity-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EBNA1BP2 →	-0.761	-1.105	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	MYCBP →	-1.006	-0.948	.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	EXOSC5 →	-0.818	-0.961	<.001	.005	3	4
LUNG_NSCLC_LUSC	RER1 →	-1.225	-1.587	.001	.001	3	4
LUNG_NSCLC_LUSC	CARMIL3 →	+0.524	+1.945	.004	<.001	3	4
BLOOD_Myeloma	PRRC2A →	-0.632	-1.834	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EBNA1BP2 by Positive regulation of phospholipase activity activity — OESOPHAGUS

Explore this box plot interactively →