Regulation of phosphatidylinositol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of phosphatidylinositol biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTR2A, PDGFB, and HTR2B, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HTR2A grouped by Regulation of phosphatidylinositol biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HTR2A →	-0.281	-1.773	<.001	<.001	2	14
KIDNEY	PDGFB →	-0.191	-1.414	<.001	<.001	3	8
URINARY_TRACT	HTR2B →	-0.295	-1.540	.006	.006	1	8
CNS	UBE2D2 →	-0.107	-0.976	.004	<.001	3	5
LUNG_SCLC	SNHG28 →	-0.140	-0.953	<.001	.004	3	4
LUNG_SCLC	ITGB3 →	+0.194	+1.009	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HTR2A by Regulation of phosphatidylinositol biosynthetic process activity — SOFT_TISSUE

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