Positive regulation of autophagy

Across TCGA cell cohorts, RNA activity of the Positive regulation of autophagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YOD1, ITGB1, and HSF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YOD1 grouped by Positive regulation of autophagy-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	YOD1 →	-2.096	-0.229	.002	<.001	3	4
CNS	ITGB1 →	-1.035	-0.608	.004	.006	3	4
LUNG_SCLC	HSF2 →	+0.926	+0.140	.002	.003	3	4
BLOOD_Leukemia	MSH3 →	-1.042	-0.224	<.001	.001	3	3
BLOOD_Leukemia	RAP1B →	-1.251	-0.188	.001	.005	3	3
BLOOD_Leukemia	STAM →	-1.629	-0.189	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YOD1 by Positive regulation of autophagy activity — BLOOD_Leukemia

Explore this box plot interactively →