Negative regulation of autophagy

Across TCGA cell cohorts, RNA activity of the Negative regulation of autophagy pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXD4, CIB1, and MET, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagy activity versus HOXD4 in LUNG_SCLC (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HOXD4 →	-1.846	-0.198	.003	.006	3	6
OVARY	CIB1 →	+1.011	+0.135	.006	.004	3	5
LARGE_INTESTINE	MET →	+1.177	+0.191	.005	.001	3	5
LARGE_INTESTINE	MYOF →	+1.576	+0.126	.002	.004	3	5
LUNG_NSCLC_LUAD	HOXC13 →	-1.352	-0.176	.008	.004	3	4
BONE	BHLHE40 →	+2.818	+0.263	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010507 vs HOXD4 — LUNG_SCLC

Explore this scatter interactively →