Intercellular transport

pathway activity — cross-omics
GO:0010496Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Intercellular transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAU, PEG10, and TSPAN8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVPLAU →+0.553+0.100<.001<.00136
UCECPEG10 →+0.802+0.346<.001<.00136
OVTSPAN8 →-1.105-0.091.005.00435
OVCRTAP →+0.389+0.106<.001<.00135
OVMMP14 →+0.383+0.095<.001<.00135
OVARHGAP26 →-0.361-0.080.001.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration