Intercellular transport

pathway activity — cross-omics
GO:0010496Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Intercellular transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM102, EPHB2, and HOXD8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADTMEM102 →-0.316-0.548.007.00134
LSCCEPHB2 →+0.631+0.627.002.00124
LSCCHOXD8 →-0.634-0.556.003.00733
PDACRNF113A →-0.189-0.262.007.00533
PDACRABGAP1L →-0.212-0.216.005.00333
PDACMPZL1 →-0.434-0.175<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration