Regulation of signaling receptor activity

Across TCGA patient cohorts, RNA activity of the Regulation of signaling receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOSR1, FCER1G, and CAPG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of signaling receptor activity activity versus GOSR1 in LSCC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GOSR1 →	-0.290	-0.470	.008	.005	3	4
UCEC	FCER1G →	+1.025	+0.775	.003	<.001	3	4
PDAC	CAPG →	+0.337	+0.418	<.001	.001	3	4
UCEC	HAVCR2 →	+0.951	+0.687	<.001	<.001	3	4
UCEC	FCGR1A →	+1.022	+0.591	<.001	<.001	3	4
UCEC	OR2A3P →	-0.596	-0.585	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010469 vs GOSR1 — LSCC

Explore this scatter interactively →